LY1: What is the distribution of B cells and T cells in the lymphatic tissue?
LY2: What is a fiber associated reticular cell?
LY3: Where do the plasma cells in the lymph node go?
LY4: How do cells travel from the blood to the lymph node?
LY5: Why is the thymic medulla lighter than the cortex?
LY6: What are the differences among the various reticular cells and fibers of the lymphoid organs?
LY7: How do lymphocytes leave the thymus?
LY8: What are the major antigen presenting cells of the tonsil, spleen and lymph node?
LY9: What are some of the defining characteristics of each of the lymphoid organs?
LY10: Where are the lymphoblasts?
LY11: Did you see free macrophages in the splenic sinuses of your sections? They frequently accumulate in this region. In addition to antigen presentation, what role do macrophages play in the spleen?
LY12: What are the functions of the red pulp?
1. Which of the following statements concerning T helper cells is true?
(A) They possess membrane-bound antibodies.
(B) They can recognize and interact with antigens in the blood.
(C) They produce numerous cytokines.
(D) They function only in cell-mediated immunity.
(E) Their activation depends on interferon-y.
2. Which of the following statements concerning T cytotoxic(T c) cells is true?
(A) They assist macrophages in killing microorganisms.
(B) They possess antibodies on their surfaces.
(C) They possess CD8 surface markers.
(D) They possess CD28 surface markers.
(E) They secrete interferon -y.
3. Which of the following cell types is thought to function in preventing immune responses against self-antigens?
(A) T s cells
(B) B cells
(C) T memory cells
(D) T H cells
(E) Mast cells
4. Which of the following statements concerning interferon -y is true?
(A) It is produced by T memory cells.
(B) It is produced by T suppressor cells.
(C) It activates macrophages.
(D) It inhibits macrophages.
(E) It induces viral proliferation.
5. A patient who was given penicillin has an adverse reaction to the antibiotic. Although the reaction is due to the actions of mast cells, the response occurred because mast cells have immunoglobulin E (IgE) receptors in their cell membranes. Which of the following cells produced the IgE decorating the plasma cell's surface?
(A) T memory cells
(B) B memory cells
(C) T helper cells
(D) Plasma cells
(E) T cytotoxic cells
6. Which of the following statements concerning the thymus is true?
(A) Lymphoid nodules form much of the thymic cortex.
(B) Epithelial reticular cells form Hassall corpuscles.
(C) T cells migrate into the medulla, where they become immunologically competent.
(D) Most T cells that enter the thymus are killed in the medulla.
(E) Macrophages are essential components of the blood-thymus barrier.
7. Which of the following statements concerning Hassall corpuscles is true?
(A) They are located in the thymic cortex of young individuals.
(B) They are located in the thymic cortex of old individuals.
(C) They are derived from mesoderm.
(D) They are located in the thymic medulla.
(E) They are derived from T memory cells.
8. After their maturation in the thymus and release into the circulation, T lymphocytes migrate preferentially to which of the following sites?
(A) Paracortex of lymph nodes
(B) Cortical lymphoid nodules of lymph nodes
(C) Hilus of lymph nodes
(D) Lymphoid nodules of the tonsils
(E) Lymphoid nodules of the spleen
9. In which of the following sites do lymphocytes become immunocompetent?
(A) Germinal center of secondary lymphoid nodules
(B) White pulp of the spleen
(C) Thymic cortex
(D) Red pulp of the spleen
(E) Paracortex of lymph nodes
10. Which of the following statements about immunoglobulin G (IgG) is true?
(A) It is located in the serum and on the membrane of B cells.
(B) It can cross the placental barrier.
(C) It is involved in allergic reactions.
(D) It exists as a pentamer.
(E) It binds to antigens on the body surface and in the lumen of the gastrointestinal tract.
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